Press Release

University of Liverpool choose CPS Disc Centrifuge to monitor coating thickness of nanoscale drug delivery vehicles

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Analytik, leading suppliers of innovative analytical instrumentation, report on use of CPS Disc Centrifuges for high resolution nanoparticle size analysis at the University of Liverpool and University College Dublin.

Multidisciplinary research projects led by Professor Mathias Brust, of the Department of Chemistry, involve the chemical modification of (6-80 nm) metal nano particles with biologically active molecules such as anti-cancer drugs, enzymes or signal peptides. The technology behind the DC24000, differential centrifugal sedimentation (DCS), allows the group to investigate particle size distributions and monitor the modification step which requires precise control over the type and number of ligands attached to the particles.

A whole range of particle sizing, spectroscopic and electrochemical techniques are available at the Centre including DLS, TEM, SEM, FTIR, NMR and SERS; the DC24000 was purchased as it deals particularly well with multi-modal size distributions.

Referring to the CPS DC24000, Professor Brust comments; ‘It is fantastic for monitoring minute thickness changes, for example those caused by chemical reactions in the ligand shell of nano particles. Although at present it is still qualitative, it is nevertheless very powerful and extremely fast and easy to do with very small amounts of material. In our hands it compares very favourably with most spectroscopic techniques’.

The CPS Disc Centrifuge delivers routine ultra high resolution analysis of nano particle populations down to 2 nm and differing in size by as little as 2%. The instrument has revolutionised nanoparticle size characterisation, proving to be an invaluable tool for countless nano applications around the World.

Further work for the group involves the investigation of quantitative measurements of molecular ligand shell thickness in monolayer protected clusters with a thickness resolution of a single C-C bond.

Cambridge-based Analytik are exclusive UK and Ireland distributors of the CPS Disc Centrifuge. To learn more about the ultra-high resolution particle sizer, visit our nanopartice size analysis page.

About…Analytik are leading suppliers of innovative analytical instrumentation to the UK and Ireland. Cutting-edge solutions from global technology providers, coupled with responsive service and flexibility has enabled the company to build an impressive customer base since forming in 2003. Analytik’s partners include Agilent Technologies, ASD Inc, SciAps, CPS Instruments and Videometer. Solutions include portable and handheld spectrometers (NIR, FTIR, Raman), spectral imaging systems, light measurement systems and nanoparticle size analysers.

For further information: Please contact Analytik direct:

Analytik Limited
2 Cygnus Business Park
Middle Watch, Swavesey
Cambridge CB24 4AA
T +44(0) 1954 232 776
F +44(0) 870 135 2488
www.analytik.co.uk
info@analytik.co.uk

 

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CPS Instruments provides researchers and scientists in various industries with the world’s fastest, highest resolution, and most sensitive Disc Centrifuge particle size analyzers.