The study, „Role of nanoparticle size and sialic acids in the distinct time-evolution profiles of nanoparticle uptake in hematopoietic progenitor cells and monocytes,“ was published in the Journal of Nanobiotechnology this month. The research seeks to discover the relationship between size of polystyrene nanoparticles and their interaction with human hematopoietic progenitor cells (HPC). These cells play a role in cancer and tissue regeneration, and so the ability to target them is of interest in cell therapy. 

The researchers studied how 40, 100, and 200 nm polystyrene nanoparticles were internalized by HPCs. The researchers conclude that, „the terminal membrane-associated sialic acids contribute to the NP retention at the outer cell membrane of HPCs. This retention behavior is a unique characteristic of the HPCs and is independent of NP size.“ In the course of their work, the researchers relied on the CPS Disc Centrifuge DC24000 for particle size analysis. 

Around the world, researchers rely on CPS Instruments when accuracy matters most. The CPS disc centrifuge provides a higher resolution than light scattering or particle counting methods at a much faster rate of analysis than competitive sedimentation-based particle sizing instruments. Whether replacing an aging system or increasing capacity with a new system, an investment in a CPS disc centrifuge is an investment in consumer confidence.